Biblioteca Científica | Cyberknife COC

Scientific Articles

At the Costa Rican Cancer Center - CyberKnife, clinical practice is supported by solid and constantly evolving scientific evidence.

This section brings together our institutional research and experience, as well as international scientific publications that support the use of robotic radiosurgery as an advanced and, in many cases, standard treatment alternative for various oncological and non-oncological pathologies. CyberKnife technology has been extensively studied in multiple clinical settings, demonstrating high levels of precision, tumor control, and preservation of healthy tissue.

Our commitment is to integrate this evidence with a personalized medical assessment, ensuring informed and patient-centered decisions.

Institutional Experience

CyberKnife Stereotactic Radiosurgery for an unusual case of large brain metastases from Ewing's sarcoma in a pediatric patient

Authors:
Mejías, R.; Bermúdez-Guzmán, L.; Blanco, A.

Year of publication:
2022

Magazine:
Advances in Radiation Oncology

Type of study:
Clinical case report

Summary:
This study describes a rare case of extensive brain metastases from Ewing sarcoma in a pediatric patient, treated with CyberKnife radiosurgery. The results demonstrate the ability of this technology to treat complex lesions with high precision, achieving tumor control in situations where therapeutic options are limited.

DOI:
https://doi.org/10.1016/j.adro.2022.100979

Brain Tumors

Pan-cancer analysis of non-oncogene addiction to DNA repair

Authors:
Bermúdez-Guzmán, L.

Year:
2021

Magazine:
Scientific Reports

Guy:
Molecular research study

Summary:
This study analyzes the dependence of different types of cancer on DNA repair mechanisms, identifying potential therapeutic vulnerabilities. Its findings contribute to the development of personalized strategies in oncology, including the use of high-precision radiotherapy.

DOI:
https://doi.org/10.1038/s41598-021-02773-3

Molecular Oncology

The Time for Chronotherapy in Radiation Oncology

Authors:
Bermúdez-Guzmán, L.; Blanco-Saborío, A.; Ramírez-Zamora, J.; Lovo, E.

Year:
2021

Magazine:
Frontiers in Oncology

Guy:
Review article

Summary:
This work explores the impact of biological time on the response to radiotherapy, proposing chronotherapy as a strategy to optimize efficacy and reduce toxicity. It represents an innovative approach within modern radiotherapy.

DOI:
https://doi.org/10.3389/fonc.2021.687672

Molecular Oncology

Stereotactic Radiosurgery for Recurrent Glioblastoma Multiforme

Authors:
Lovo, E.; Moreira, A.; Barahona, K.; et al.

Year:
2021

Magazine:
Cureus

Guy:
Retrospective multicenter study

Summary:
This multicenter study evaluates the use of stereotactic radiosurgery in recurrent glioblastoma, showing promising results in tumor control and management of advanced disease.

DOI:
https://doi.org/10.7759/cureus.18480

Brain Tumors

CyberKnife Stereotactic Radiosurgery for Uveal Melanoma

Authors:
Benavides, R.; Mejías, R.; Blanco, A.; Bermúdez-Guzmán, L.

Year:
2023

Magazine:
Ocular Oncology and Pathology

Guy:
Case series

Summary:
First case series in Central America on the use of CyberKnife in uveal melanoma. Demonstrates the viability and effectiveness of the treatment in ocular tumors.

DOI:
https://doi.org/10.1159/000534207

Eye Tumors

CyberKnife SBRT for Renal Cell Carcinoma

Authors:
Soto-Monge, T.; Mejías, R.; Bermúdez-Guzmán, L.

Year:
2022

Magazine:
Journal of Onco-Nephrology

Guy:
Clinical case

Summary:
It presents a complex case of renal carcinoma in a patient with unilateral renal agenesis treated with SBRT using CyberKnife, showing safety and effectiveness in complex clinical situations.

DOI:
https://doi.org/10.1177/23993693221123345